Cancer and neurodegenerative disorders: Pathogenic convergence through microRNA regulation

  • Ujwal Kumar Global College of Pharmacy, Moinabad, Hyderabad, Telangana State, India
  • M K Aneebuddin Department of Pharmaceutics, Shadan College of Pharmacy, Telangana State, India


Despite the fact that cancer and neurodegenerative disorders are two separate diseases with unique pathology, it can be construed from emerging pieces of evidence that these two types of diseases share common mechanisms of genetic and molecular abnormalities. Recent studies and current understanding show that individual microRNAs (miRNAs) may be involved in the pathology of these two apparently diverse diseases, indicating that there is a common mechanism that leads to the theory of dysregulation in gene expression at the post-transcriptional level. Several miRNA-based therapeutic approaches have shown efficacy in the modulation of activities of miRNAs, indicating their potential to treat a number of pathological conditions.  On the same lines, the role of miRNAs in the converging pathways of leading both diseases suggests good prospects for developing common therapeutic strategies for both diseases. Not only for therapeutic approaches, but the miRNAs also dysregulated in both diseases might be promisingly viewed as uniquely informative diagnostic markers. In this paper, we review recent studies on the miRNAs involved in both cancer and neurodegenerative diseases.


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Zahreddine, H., & Borden, K. (2013). Mechanisms and insights into drug resistance in cancer. Fron-tiers in pharmacology, 4, 28.

Goodwin, J. F., Schiewer, M. J., Dean, J. L., Schre-cengost, R. S., de Leeuw, R., Han, S., ... & Knudsen, K. E. (2013). A hormone–DNA repair circuit gov-erns the response to genotoxic insult. Cancer dis-covery, 3(11), 1254-1271.

Poche, D. M., Garlapati, R. B., Mukherjee, S., Torres-Poché, Z., Hasker, E., Rahman, T., ... & Poché, R. M. (2018). Bionomics of Phlebotomus argentipes in villages in Bihar, India with insights into efficacy of IRS-based control measures. PLoS neglected tropical diseases, 12(1), e0006168.

Filipič, M. (2012). Mechanisms of cadmium in-duced genomic instability. Mutation Re-search/Fundamental and Molecular Mechanisms of Mutagenesis, 733(1-2), 69-77.

Li, L., Hu, S., & Chen, X. (2018). Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities. Biomaterials, 171, 207-218.

Langie, S. A., Koppen, G., Desaulniers, D., Al-Mulla, F., Al-Temaimi, R., Amedei, A., ... & Collins, A. R. (2015). Causes of genome instability: the effect of low dose chemical exposures in modern society. Carcinogenesis, 36(Suppl_1), S61-S88.

Mishra, A., Nizammuddin, S., Mallick, C. B., Singh, S., Prakash, S., Siddiqui, N. A., ... & Thangaraj, K. (2017). Genotype-phenotype study of the middle Gangetic plain in India shows association of rs2470102 with skin pigmentation. Journal of In-vestigative Dermatology, 137(3), 670-677.

Bhattacharjee, P., Banerjee, M., & Giri, A. K. (2013). Role of genomic instability in arsenic-induced car-cinogenicity. A review. Environment international, 53, 29-40.

Tu, T., Budzinska, M. A., Maczurek, A. E., Cheng, R., Di Bartolomeo, A., Warner, F. J., ... & Shackel, N. A. (2014). Novel aspects of the liver microenviron-ment in hepatocellular carcinoma pathogenesis and development. International journal of molecu-lar sciences, 15(6), 9422-9458.

Friboulet, L., Barrios-Gonzales, D., Commo, F., Olaussen, K. A., Vagner, S., Adam, J., ... & Soria, J. C. (2011). Molecular characteristics of ERCC1-negative versus ERCC1-positive tumors in resected NSCLC. Clinical Cancer Research, 17(17), 5562-5572.

Thakur, J., & Sanyal, K. (2013). Efficient neocen-tromere formation is suppressed by gene conver-sion to maintain centromere function at native physical chromosomal loci in Candida albicans. Genome Research, 23(4), 638-652.

Yadav, M. P., Padmanabhan, S., Tripathi, V. P., Mishra, R. K., & Dubey, D. D. (2012). Analysis of stress-induced duplex destabilization (SIDD) prop-erties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe. BMC research notes, 5(1), 1-10.

Lim, H. K., Asharani, P. V., & Hande, M. P. (2012). Enhanced genotoxicity of silver nanoparticles in DNA repair deficient mammalian cells. Frontiers in genetics, 3, 104.

Yue, J., Huhn, S., & Shen, Z. (2013). Complex roles of filamin-A mediated cytoskeleton network in cancer progression. Cell & bioscience, 3(1), 1-12.

Bosch-Presegue, L., & Vaquero, A. (2014). Sirtuins in stress response: guardians of the genome. Onco-gene, 33(29), 3764-3775.

YináZhang, K. (2015). A multifunctional phospho-rescent iridium (III) complex for specific nucleus staining and hypoxia monitoring. Chemical Com-munications, 51(37), 7943-7946.

Pratihar, A. S., Tripathi, V. P., Yadav, M. P., & Dubey, D. D. (2015). Chromosomal context and replication properties of ARS plasmids in Schiz-osaccharomyces pombe. Journal of biosciences, 40(5), 845-853.

Santibáñez-Andrade, M., Quezada-Maldonado, E. M., Osornio-Vargas, Á., Sánchez-Pérez, Y., & García-Cuellar, C. M. (2017). Air pollution and genomic instability: The role of particulate matter in lung carcinogenesis. Environmental pollution, 229, 412-422.

Rauti, R., Musto, M., Bosi, S., Prato, M., & Ballerini, L. (2019). Properties and behavior of carbon na-nomaterials when interfacing neuronal cells: How far have we come?. Carbon, 143, 430-446.

MacKinnon, R. N., & Campbell, L. J. (2011). The role of dicentric chromosome formation and sec-ondary centromere deletion in the evolution of myeloid malignancy. Genetics research interna-tional, 2011.

Tripathi, V. P., & Dubey, D. D. (2017). A replica-tion-time-controlling sequence element in Schiz-osaccharomyces pombe. Chromosoma, 126(4), 465-471.

Wang, J., Zhou, L., Li, Z., Zhang, T., Liu, W., Liu, Z., ... & Shen, B. (2015). YY1 suppresses FEN1 over-expression and drug resistance in breast cancer. BMC cancer, 15(1), 1-15.

Kurelac, I., MacKay, A., Lambros, M. B., Di Cesare, E., Cenacchi, G., Ceccarelli, C., ... & Gasparre, G. (2013). Somatic complex I disruptive mitochon-drial DNA mutations are modifiers of tumorigene-sis that correlate with low genomic instability in pituitary adenomas. Human molecular genetics, 22(2), 226-238.

Leung, W., Baxley, R. M., Moldovan, G. L., & Biel-insky, A. K. (2018). Mechanisms of DNA damage tolerance: Post-translational regulation of PCNA. Genes, 10(1), 10.

Tripathi, V. P., Aneebuddin, M. K., Alex, C., & Mo-harir, K. S. (2021). Evaluating Clinical Applications of Liquid Biopsy by Combining Circulating Tumor DNA and Tumor cells. Current Research in Phar-maceutical Sciences, 107-111.

Vodenkova, S., Polivkova, Z., Musak, L., Smerhov-sky, Z., Zoubkova, H., Sytarova, S., ... & Vodicka, P. (2015). Structural chromosomal aberrations as po-tential risk markers in incident cancer patients. Mutagenesis, 30(4), 557-563.

Yang, H. L., Chen, S. C., Lin, K. Y., Wang, M. T., Chen, Y. C., Huang, H. C., ... & Hseu, Y. C. (2011). Antioxi-dant activities of aqueous leaf extracts of Toona sinensis on free radical-induced endothelial cell damage. Journal of ethnopharmacology, 137(1), 669-680.

Andriani, G. A., Vijg, J., & Montagna, C. (2017). Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain. Mecha-nisms of ageing and development, 161, 19-36.

Tripathi, V. P., Goo, D., Maidya, B. N., & Aneebud-din, M. K. (2022). New Trends in Interrelation of Infectious Colorectal Cancer with Intestinal Micro-biota. Arch Gastroenterol Res, 3(1), 18-22.

Müllner, E., Brath, H., Nersesyan, A., Nitz, M., Petschnig, A., Wallner, M., ... & Wagner, K. H. (2014). Nuclear anomalies in exfoliated buccal cells in healthy and diabetic individuals and the impact of a dietary intervention. Mutagenesis, 29(1), 1-6.

Zhang, X., Jia, D., Liu, H., Zhu, N., Zhang, W., Feng, J., ... & Li, B. (2013). Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential. PLoS One, 8(5), e62527.

Huang, Y. Y., Dai, L., Gaines, D., Droz-Rosario, R., Lu, H., Liu, J., & Shen, Z. (2013). BCCIP suppresses tumor initiation but is required for tumor progres-sion. Cancer research, 73(23), 7122-7133.

Tripathi, V. P., & Jetsu, R. (2022). Traditional Herbs Role in Enhancement of Antitumor Responses of Agonistic CD40-Antibody by Reducing Myeloid-derived Suppressor Cells. Chem. Res. J, 7, 1-5.

Hughesman, C. B., Lu, X. D., Liu, K. Y., Zhu, Y., Poh, C. F., & Haynes, C. (2016). A robust protocol for us-ing multiplexed droplet digital PCR to quantify so-matic copy number alterations in clinical tissue specimens. PloS one, 11(8), e0161274.

Pawlowska, E., & Blasiak, J. (2015). DNA repair—a double-edged sword in the genomic stability of cancer cells—the case of chronic myeloid leuke-mia. International journal of molecular sciences, 16(11), 27535-27549.

Thanasopoulou, A., Stravopodis, D. J., Dimas, K. S., Schwaller, J., & Anastasiadou, E. (2012). Loss of CCDC6 affects cell cycle through impaired intra-S-phase checkpoint control. PloS one, 7(2), e31007.

Lu, H., Huang, Y. Y., Mehrotra, S., Droz-Rosario, R., Liu, J., Bhaumik, M., ... & Shen, Z. (2011). Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS ge-netics, 7(9), e1002291.

Tripathi, V. P., Ahmed, H., Renulos, N., & Aneebud-din, M. K. (2022). Elucidating the Role of Chemo-kines in Infectious Diseases and Gastric Cancer. Arch Gastroenterol Res, 3(1), 23-26.

Browning, C. L., & Wise Sr, J. P. (2017). Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins. Toxicology and applied pharmacology, 331, 101-107.

Jönsson, K. I. (2019). Radiation tolerance in tardi-grades: current knowledge and potential applica-tions in medicine. Cancers, 11(9), 1333.

Smith, M. T., Guyton, K. Z., Kleinstreuer, N., Borrel, A., Cardenas, A., Chiu, W. A., ... & Fielden, M. (2020). The key characteristics of carcinogens: re-lationship to the hallmarks of cancer, relevant bi-omarkers, and assays to measure them. Cancer Ep-idemiology and Prevention Biomarkers, 29(10), 1887-1903.

How to Cite
Kumar, U., & Aneebuddin, M. K. (2022). Cancer and neurodegenerative disorders: Pathogenic convergence through microRNA regulation. International Journal of Research in Pharmaceutical Sciences and Technology, 3(1), 20-24.
Review Article